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Death of the father: British scientists discover how to turn women's bone marrow into sperm
By FIONA MACRAE - More by this author »

Last updated at 09:28am on 31st January 2008

http://www.dailymail.co.uk/pages/live/articles/technology/technology.html?in_article_id=511391&in_page_id=1965

Bye bye baby: The new science means the biological role of the father is under threat

British scientists are ready to turn female bone marrow into sperm, cutting men out of the process of creating life.

The breakthrough paves the way for lesbian couples to have children that are biologically their own.


Gay men could follow suit by using the technique to make eggs from male bone marrow.


Researchers at Newcastle upon Tyne University say their technique will help lead to new treatments for infertility.


But critics warn that it sidelines men and raises the prospect of babies being born through entirely artificial means.


The research centres around stem cells - the body's 'mother' cells which can turn into any other type of cell.


According to New Scientist magazine, the scientists want to take stem cells from a woman donor's bone marrow and transform them into sperm through the use of special chemicals and vitamins.


Newcastle professor Karim Nayernia has applied for permission to carry out the work and is ready to start the experiments within two months.


The biologist, who pioneered the technique with mice, believes early- stage 'female sperm' could be produced inside two years. Mature sperm capable of fertilising eggs might take three more years.


Early-stage sperm have already been produced from male bone marrow.


Taking stem cells from an adult donor - possibly a cancer patient - removes the ethical problems associated with using embryos.
The race to find a cure for infertility is global.

Greg Aharonian, a U.S. analyst who is trying to patent the technologies behind female sperm and male eggs, said he wants to undermine the argument that heterosexual marriage is superior because it is aimed at procreation. "I'm a troublemaker," he said.


Researchers at the Butantan Institute in Brazil, meanwhile, claim to have turned embryonic stem cells from male mice into both sperm and eggs. They are now working on skin cells.


If their experiments succeed, the stage would be set for a gay man to donate skin cells that could be used to make eggs.


These could then be fertilised by his partner's sperm and placed into the womb of a surrogate mother.


Irina Kerkis, a researcher at the Brazilian centre, said this development is possible, but raises ethical questions.


Laboratory-grown sperm and eggs offer hope for those left infertile by radiotherapy treatment when they were young.


The experiments could also provide an invaluable insight into dealing with infertility, a little understood condition that affects one in six couples.


Other scientists warn however that the research is still in its infancy and any treatment is still many years away from use in hospitals and clinics.


There are also fears that children born from artificial eggs and sperm will suffer severe health problems, like the mice in the Newcastle experiments.

Couples who have children from artificial sperm created from women would be able to have girls only. This is because the female sperm would lack the Y-chromosome needed for boys.


Robin Lovell-Badge, of the National Institute for Medical Research in London, said the creation of female sperm is at least a decade away.


Josephine Quintavalle, of Comment on Reproductive Ethics, a campaign group, said: "We are looking at absurd solutions to very obscure situations and not addressing the main issue. Nobody is interested in looking at what is causing infertility - social reasons such as obesity, smoking and age.


"All these things would provide solutions which wouldn't grab the headlines, but a lot more people would get the response they want - which is to be able to have their own children."


Mike Judge, of the Christian Institute faith group, said the Newcastle project flies in the face of research showing that children do best when raised by a married mixed- sex couple.


"Children need male and female role models in their lives," he added. "Yes, there are children raised by single parents through all sorts of circumstances, but when you are talking about deliberately creating children in that way, that is morally wrong."

Debra Matthews, a U.S. bioethicist, said: "People want children and no one wants anyone else to tell them they can't have them."


An update of Britain's ageing fertility laws is going through Parliament and is likely to allow the use of artificial sperm and eggs in IVF treatment - but only for heterosexual couples.


The Newcastle research also paves the way for a woman to grow her own sperm and use it to fertilise her natural eggs, creating a child to which she is both mother and father.


Similarly, a man could be both father and mother to a child created with his own sperm and a lab-grown egg. Such children would be at high risk of genetic abnormality.

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I just post the stories, for interest.. for everyone

Lord, what fools these mortals be!
- A Midsummer Night’s Dream, Act III, Scene ii

Voltaire said: "Those who can make you believe absurdities can make you commit atrocities."

H.L.Mencken wrote:"The whole aim of practical politics is to keep the populace alarmed (and hence clamorous to be led to safety) by menacing it with an endless series of hobgoblins, all of them imaginary.”

Only two things are infinite, the universe and human stupidity, and I'm not sure about the former. Albert Einstein

I noticed the statement in the article "the race to find the cure for infertility..
What this world needs is more farking infertility.

Well they still need a man to fund the whole operation...

but for how much longer..

*********************************************************************************************************************************
I just post the stories, for interest.. for everyone

Lord, what fools these mortals be!
- A Midsummer Night’s Dream, Act III, Scene ii

Voltaire said: "Those who can make you believe absurdities can make you commit atrocities."

H.L.Mencken wrote:"The whole aim of practical politics is to keep the populace alarmed (and hence clamorous to be led to safety) by menacing it with an endless series of hobgoblins, all of them imaginary.”

Only two things are infinite, the universe and human stupidity, and I'm not sure about the former. Albert Einstein

Fucking hell, it gets worse, doesn't it?

Playing mad scientist or God to indulge everyone's whims?

While children without families or homes continue to rot in foster homes.=P

I wonder how freaky the babies would be if this came to fruition.
There are already enough problems with the babies born through articifial means. More baybees will probably suffer, and martyr breeders get off on that. ::gag::

it never gets better, proper. soon there will be vat grown people.

*********************************************************************************************************************************
I just post the stories, for interest.. for everyone

Lord, what fools these mortals be!
- A Midsummer Night’s Dream, Act III, Scene ii

Voltaire said: "Those who can make you believe absurdities can make you commit atrocities."

H.L.Mencken wrote:"The whole aim of practical politics is to keep the populace alarmed (and hence clamorous to be led to safety) by menacing it with an endless series of hobgoblins, all of them imaginary.”

Only two things are infinite, the universe and human stupidity, and I'm not sure about the former. Albert Einstein

Mercurior said, "it never gets better, proper. soon there will be vat grown people."

"Mmmm. Soylent Green."—Homer Simpson

"its dead people, Soylant green is dead people"

*********************************************************************************************************************************
I just post the stories, for interest.. for everyone

Lord, what fools these mortals be!
- A Midsummer Night’s Dream, Act III, Scene ii

Voltaire said: "Those who can make you believe absurdities can make you commit atrocities."

H.L.Mencken wrote:"The whole aim of practical politics is to keep the populace alarmed (and hence clamorous to be led to safety) by menacing it with an endless series of hobgoblins, all of them imaginary.”

Only two things are infinite, the universe and human stupidity, and I'm not sure about the former. Albert Einstein

I wish people could just get over their own fucking DNA. No! You are not special--you're just another asshole like all the rest of us. If you need a baby that badly, adopt already. Fucking narcissistic, self-important pricks...

guest Wrote:
-------------------------------------------------------
> I wish people could just get over their own
> fucking DNA. No! You are not special--you're just
> another asshole like all the rest of us. If you
> need a baby that badly, adopt already. Fucking
> narcissistic, self-important pricks...

http://www.cafepress.com/oopsforgotbaby.14036713

This is a perfect tee stating how breeding is really nothing more than narcissism. Notice how breeders love to say, "MY child...," all of the time.

guest Wrote:
-------------------------------------------------------
> I wish people could just get over their own
> fucking DNA. No! You are not special--you're just
> another asshole like all the rest of us. If you
> need a baby that badly, adopt already. Fucking
> narcissistic, self-important pricks...

I totally agree. Contrary to what they tell us CF, breeders are the selfish ones, breeding only so they can have a 'mini-me' and parade it around, thus adding to the overcrowding of the planet.

I always caution people about the long-term relevance and utility of new medical technologies, because most of what we hear to be "new" miracle cures, biochemical pathways, etc., carry significant risks that are not discovered until much later. I point to the several cancer medications that we now know carry significant long-term risks such as other forms of cancer many years after their clinical use. For example, a commonly used chemotherapy agent named bleomycin carries a significant warning about the development of pulmonary fibrosis. Other medications in the same class carry warnings about increased risk of other oncologic disorders like leukemias, etc.

For all we have identified, it takes years to formally translate laboratory benchwork properly to the bedside. There are a few notable examples that were rushed based on dire medical necessity, but a price was paid in the form of sequelae (med-speak for side-effects) months to years after clinical use of these new molecular entities (drugs) or technologies (devices).

The other reason to be concerned is quite frankly the genetic diversity proven necessary in non-experimental animal models by mother nature herself. The more genetically diverse a population is, the healthier it will be. The technology described is neither diverse nor is it broad enough to support wider use at this time.